Niacinamide

I continue to explore new options, and niacinamide caught my attention a few months ago. I have ordered it from iHerb and expect to receive it end of December 2025 and will start a few months treatment with it starting January, just to see if it has any impact. Preclinical trials seem promising.

Niacinamide, also known as nicotinamide, is the amide form of vitamin B3, a water-soluble nutrient essential for energy metabolism, DNA repair, and cellular stress responses.pmc.ncbi.nlm.nih

Preclinical studies on prostate cancer cells indicate niacinamide may suppress malignant traits like invasion and migration by inhibiting SIRT1 expression, a protein upregulated by nicotinamide N-methyltransferase (NNMT), which is elevated in prostate tumors. NNMT overexpression promotes PC-3 cell aggressiveness, but niacinamide counters this by downregulating SIRT1, suggesting a potential role in curbing progression; however, no clinical trials confirm direct benefits for prostate cancer treatment or prevention in humans.library+4

Niacinamide shows stronger clinical evidence for reducing non-melanoma skin cancers by 23-50%, particularly basal and squamous cell types, via enhanced DNA repair and immune response. Other supported uses include improving acne, slowing type 1 diabetes progression, lowering high phosphate in kidney patients, easing osteoarthritis symptoms, and aiding erectile function in men with dyslipidemia.news.vumc+4

Suggested doses draw from studied applications: 500 mg twice daily (1,000 mg total) for skin cancer prevention and theoretical prostate support. Doses up to 1,500 mg daily appear well-tolerated with minimal side effects like mild stomach upset, but monitor liver function above 1,000 mg and consult a provider, especially alongside saw palmetto or other supplements.library+4

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